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[OM] OT Coronary Heart Disease (CHD) [was Cholesterol again...]

Subject: [OM] OT Coronary Heart Disease (CHD) [was Cholesterol again...]
From: usher99@xxxxxxx
Date: Fri, 15 Dec 2006 23:30:10 -0500
 Hi Moose,
 Yes I get an unlimited access to Ovid with my academic appointment. Perhaps 
these are of interest. If they were easily available full text on line, I would 
have fwd'd them to your e-mail if desired. I can still get any of them Monday, 
if if you like. Give me a quick ping for any searches in the future or any 
articles---it takes a minute.
 
 Mike (quite "type A", determined to die healthy, and card carrying member of 
the statin washed down with Olde Browne Dog club) 
 
 Moose:
 "I don't know if the results of that study have been published. Dr. 

Freidman died near the end of the project and that may have delayed 

things. And I don't even know where to look; these things don't seem to 

show up in web searches. Probably only on subscription services? "
 
 
 
 
 
 
 Ovid MEDLINE(R) 1966 to November Week 3 2006  Results of your search: from 3 
[1 and 2] keep 1, 5-6   Results Available: 3
 Results Displayed: 1-3    Result 1. 
 Unique Identifier8892763

 AuthorsFriedman M. Breall WS. Goodwin ML. Sparagon BJ. Ghandour G. Fleischmann 
N.

 Authors Full NameFriedman, M. Breall, W S. Goodwin, M L. Sparagon, B J. 
Ghandour, G. Fleischmann, N.

 InstitutionMeyer Friedman Institute, UCSF-Mount Zion Medical Center, San 
Francisco, Calif. 94143-1680, USA.

 TitleEffect of type A behavioral counseling on frequency of episodes of silent 
myocardial ischemia in coronary patients.

 SourceAmerican Heart Journal. 132(5):933-7, 1996 Nov.

 AbstractThirteen of 32 patients with coronary heart disease who also exhibited 
symptoms and signs of severe time urgency and hostility (the two overt 
components of type A behavior [TAB]) were found to exhibit multiple episodes of 
silent myocardial ischemia over a 48-hour period of Holter monitoring as 
indicated by electrocardiogram ST depressions. Ten of these 13 patients were 
given 14 months of TAB counseling in an attempt to diminish the intensity of 
their time urgency and hostility. The remaining three patients served as 
controls. After counseling, the intensity of the time urgency and hostility of 
the 10 counseled patients diminished 53% and 59%, respectively, as measured by 
the videotaped clinical examination. The time urgency and hostility of the 
three uncounseled control patients did not significantly change. The mean 
frequency of ischemic episodes in the 10 patients who received TAB counseling 
significantly declined from an initial 6.6 to 3.1 ischemic episodes per 24
  hours. However, the mean frequency of ischemic episodes did not significantly 
decline in 2 of the 3 uncounseled patients. The third uncounseled patient 
developed a conduction defect in the 14-month interlude, making an analysis of 
his repeat 48-hour electrocardiogram for episodes of ST depression impossible.

 Publication TypeJournal Article.

   Result 2. 
  Unique Identifier3630890

 AuthorsFriedman M. Powell LH. Thoresen CE. Ulmer D. Price V. Gill JJ. Thompson 
L. Rabin DD. Brown B. Breall WS. et al.

 Authors Full NameFriedman, M. Powell, L H. Thoresen, C E. Ulmer, D. Price, V. 
Gill, J J. Thompson, L. Rabin, D D. Brown, B. Breall, W S. et al.

 TitleEffect of discontinuance of type A behavioral counseling on type A 
behavior and cardiac recurrence rate of post myocardial infarction patients.

 SourceAmerican Heart Journal. 114(3):483-90, 1987 Sep.

 AbstractThree hundred post infarction participants who had received type A 
behavioral counseling in the Recurrent Coronary Prevention Project, (RCPP) 
agreed to be followed for 1 additional year after stopping 4.5 years of 
continuous type A behavioral counseling. One hundred fourteen participants who 
had served for 4.5 years as controls in the RCPP Study, thus receiving no type 
A behavioral counseling, volunteered to receive such counseling for 1 year. 
Eleven of the 300 previously type A counseled RCPP participants were lost to 
follow-up at the end of the additional year. The remaining 289 subjects at risk 
were found to have maintained their previously reduced intensity of type A 
behavior. Their previously observed relatively low cardiac recurrence rate 
during the additional year also did not significantly change. Ten of the 114 
previous control RCPP participants were lost to follow-up at the end of the 
additional year. The remaining 104 subjects who had received a year's typ
 e A behavioral counseling showed a significantly reduced intensity of type A 
behavior and a similar significant decrease in both the cardiac mortality and 
morbidity rate. These results suggest that the decline in the intensity of type 
A behavior and also in the cardiac recurrence rate previously observed in post 
infarction subjects exposed to type A behavioral counseling persists for at 
least 1 year after cessation of such counseling.

 Publication TypeClinical Trial. Journal Article. Randomized Controlled Trial.

   Result 3. 
  Unique Identifier3766365

 AuthorsFriedman M. Thoresen CE. Gill JJ. Ulmer D. Powell LH. Price VA. Brown 
B. Thompson L. Rabin DD. Breall WS. et al.

 Authors Full NameFriedman, M. Thoresen, C E. Gill, J J. Ulmer, D. Powell, L H. 
Price, V A. Brown, B. Thompson, L. Rabin, D D. Breall, W S. et al.

 TitleAlteration of type A behavior and its effect on cardiac recurrences in 
post myocardial infarction patients: summary results of the recurrent coronary 
prevention project.

 SourceAmerican Heart Journal. 112(4):653-65, 1986 Oct.

 AbstractOne thousand thirteen post myocardial infarction patients were 
observed for 4.5 years to determine whether their type A (coronary-prone) 
behavior could be altered and the effect such alteration might have on the 
subsequent cardiac morbidity and mortality rates of these individuals. Eight 
hundred sixty-two of these individuals were randomly assigned either to a 
control section of 270 participants who received group cardiac counseling or an 
experimental section of 592 participants who received both group cardiac 
counseling and type A behavioral counseling. The remaining 151 patients, 
serving as a "comparison group," did not receive group counseling of any kind. 
Using the "Intention-to-Treat" principle, we observed markedly reduced type A 
behavior at the end of 4.5 years in 35.1% of participants given cardiac and 
type A behavior counseling compared with 9.8% of participants given only 
cardiac counseling. The cumulative 4.5-year cardiac recurrence rate was 12.9% 
in the 5
 92 participants in the experimental group that received type A counseling. 
This recurrence rate was significantly less (p less than 0.005) than either the 
recurrence rate (21.2%) observed in the 270 participants in the control group 
or the recurrence rate (28.2%) in those of the comparison group not receiving 
any special treatment. After the first year, a significant difference in number 
of cardiac deaths between the experimental and control participants was 
observed during the remaining 3.5 years of the study. Overall, the results of 
this study demonstrate for the first time, within a controlled experimental 
design, that altering type A behavior reduces cardiac morbidity and mortality 
in post infarction patients.

 Publication TypeClinical Trial. Journal Article. Randomized Controlled Trial.

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