Yes, PAD could be a special case but Dr. Cooke still thought it prudent
to withdraw all his previous advice. The fact that it's only one paper
is not a surprise as Dr. Cooke is about the only guy around who has
actually done clinical research on L-arginine. Your other sources have
never published any of their work. How come?
I've told you what I know. You may choose to believe whatever you want.
Chuck Norcutt
On 7/28/2013 11:07 AM, Brian Swale wrote:
> Chuck wrote:
>> You should know well
>> that the original recommendation for the use of large quantities of
>> L-arginine originated with the research of Dr. John P. Cooke of Stanford
>> and publicized in his book "The Cardiovascular Cure". Dr Cooke replied
>> "Yes, the book needs to be updated to take into account the new data, one
>> of which papers is mine(the one from Stanford published in Circulation in
>> 2007, showing no benefit and potential vascular harm from chronic use of
>> Arginine in patients with Peripheral arterial disease. Accordingly I no
>> longer recommend l-Arginine supplementation for heart and vessel health."
>
> Peripheral Arterial Disease seems to be a special case. And that is just ONE
> paper.
>
> I also have the book written by Dr Joe Prendergast (Endocrinologist based
> near Stanford where Dr Cooke was based) (ISBN 1-59975-022-8)
> http://www.theuncommondoctor.com
> Prendergast went to Cooke when, at the age of 37, he was shown by CAT
> scan to have severe clogging of his abdominal arteries. The technician
> dealing with him told him he had the disorder to the degree normally seen in
> 80-year+ olds. He knew his family had a history of premature death and
> disability through heart attack. He went for advice to Cooke who
> recommended L-arginine, at an initial rate of 1 gm per day, later increased
> to up to 6 gm per day.
>
> Remember, L-arginine is a normal component of our daily food, not
> something foreign to the body.
>
> Ten years later, Prendergast needed another CAT scan of his abdomen (
> same technician ) who was amazed to find the athersclerosis had ALL
> vanished. He then went to get other scans done, including of his coronary
> arteries, and they were ALL clear. See pp 113 et sequ of his book.
>
> Prendergast started putting his diabetic patients on a course of L-arginine.
> Over a period of about 18 years this amounted to five thousand (5,000)
> people. Normally, diabetics have a heart disease rate of about 30%+
> Prendergast writes in 2006 (quote) "Since 1991,my practice has not had
> (even (ed)) one patient suffer from a heart attack or stroke. It gives me
> great
> satisfaction to report that we have virtually reversed all heart disease, even
> in the patients who have other diabetes-related problems" (end quote)
>
> I asked Dr Prendergast if he took any special dietary precautions as well.
> HE REPLIED THAT HE DID NOT. ( Emphasis, not shouting).
>
> The recipes in Cooke's book do permit some meat etc, although I find the
> detail of his recipes too abstruse and complicated for me.
>
> Also, the Med diet(s) follow a general line of thought within which there is
> scope for a lot of variation. A recent spanish study involving ?? 7500
> patients showed that the normal Western premature death rate from heart
> disease could be reduced by 25% of its 30 - 34% usual rate. That is an
> improvement, but not an excellent result.
> Certainly not in the same league achieved by Dr Prendergast.
>
> I consider that Dr Prendergast's evidence of 5,000 actual patients over an
> 18 year period being totally saved from a 30%+ rate of premature
> death/disability, to carry considerably more weight of evidence than just
> ONE paper, dealing with ONE special situation (Peripheral Arterial Disease -
> ie of the legs)
> The medical journal reference people ignore the kind of evidence given by
> Dr Prendergast, because it doesn't suit their evidence model.
>
> I have also seen at least one paper which shows that people who have had
> an infarction ( ruptured plaque pustule) can be killed through subsequent
> augmented supply of L-arginine.
>
> But as far as I can see, Maggie did not have that - "only" severe clogging :-(
>
> Yes, I'd like to see Cooke come out with a revision of his book too.
>
> It's interesting that a major literature review used by the NZ Ministry of
> Health regarding heart disease, was published the same year that Cooke
> wrote his book. 2002. They are both 13 years old.
>
> All related heart health care providers in NZ follow this outdated database
> :-(
>
> By the way, it is on record that Nathan Pritikin, who promoted a meat-free
> diet much the same as Dr Esselstyn, was found after his premature death (
> suicide - he had a cancer that ( as far as I remember predated him starting
> his diet)) to have NO atherosclerosis. His arteries were clear of clogging, as
> shown through autopsy.
>
> L-arginine is used not only by people who want to ward off and/or reverse
> heart / arterial disease, but by body-builders as well. And they use bigger
> doses.
>
> If it is as bad as that one paper of Dr Cooke's would have it, I do expect
> there must be a storm of papers saying so. I haven't seen anything pointing
> to that.
>
> Brian Swale
>
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